Serum cystatin C as a determinant of glomerular filtration rate in children

Clin Nephrol. 1998 Apr;49(4):221-5.


The serum levels of cystatin C and creatinine were determined in a population comprising 69 children, 1-16 years old, and including children with both normal and reduced glomerular filtration rate (GFR) as determined by Cr-EDTA clearance measurement. The overall correlation between the reciprocal cystatin C concentration and GFR was significantly stronger (p < 0.05) than that between the reciprocal creatinine concentration and GFR and this was true also for the subpopulation of children with reduced GFR. Receiver-operating characteristic analysis also indicated superior diagnostic accuracy of serum cystatin C compared to that of serum creatinine for reduced GFR. The serum cystatin C reference values (mean +/- 1.96 SD) determined for children over one year of age was 0.63-1.33 mg/l, which is similar to that previously determined for adults. Serum cystatin C appears to be an attractive alternative to creatinine for estimation of GFR not only in adults, but also in children.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Chromium Radioisotopes
  • Creatinine / blood
  • Cystatin C
  • Cystatins / blood*
  • Cysteine Proteinase Inhibitors / blood*
  • Edetic Acid
  • Female
  • Glomerular Filtration Rate / physiology*
  • Humans
  • Immunoassay
  • Infant
  • Kidney Diseases / blood
  • Kidney Diseases / diagnosis*
  • Male
  • ROC Curve
  • Sensitivity and Specificity


  • CST3 protein, human
  • Chromium Radioisotopes
  • Cystatin C
  • Cystatins
  • Cysteine Proteinase Inhibitors
  • Edetic Acid
  • Creatinine