Bilateral renal cortical necrosis associated with cefuroxime axetil

Clin Nephrol. 1998 Apr;49(4):268-70.


Cefuroxime axetil has been associated with few reported adverse effects. We report a case of bilateral renal cortical necrosis in a female after receiving 7 doses over 4 treatment days. The patient presented with worsening symptoms consisting of arthralgias, pruritus, and abdominal pain. Laboratory data obtained was indicative of worsening renal failure and thrombocytopenia. The patient required hemodialysis by the third day. Kidney biopsy revealed cortical necrosis. The possible pathogenesis of cefuroxime axetil causing cortical necrosis in this case and a review of other reported cases of chemical induced renal cortical necrosis is discussed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Bronchiolitis / drug therapy*
  • Cefuroxime / adverse effects
  • Cefuroxime / analogs & derivatives*
  • Cephalosporins / adverse effects*
  • Diabetes Mellitus, Type 2 / complications
  • Female
  • Humans
  • Kidney / pathology
  • Kidney Cortex Necrosis / chemically induced*
  • Kidney Cortex Necrosis / pathology
  • Kidney Cortex Necrosis / therapy
  • Kidney Failure, Chronic / chemically induced*
  • Kidney Failure, Chronic / therapy
  • Middle Aged
  • Renal Dialysis


  • Cephalosporins
  • Cefuroxime
  • cefuroxime axetil