Emerging targets for the development of novel antifungal therapeutics

Trends Microbiol. 1998 Mar;6(3):117-24. doi: 10.1016/s0966-842x(97)01206-7.


Invasive mycoses have become important causes of morbidity and mortality in immunocompromised patients. New approaches for antifungal therapy are required to meet the challenges imposed by these life-threatening infections. Such approaches are being developed through identification of novel biochemical and molecular targets of pathogenic fungi.

Publication types

  • Review

MeSH terms

  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology*
  • Cell Membrane / chemistry
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism
  • Cell Wall / chemistry
  • Cell Wall / drug effects
  • DNA, Fungal / metabolism
  • Fungal Proteins / biosynthesis
  • Peptide Elongation Factors / biosynthesis
  • Signal Transduction


  • Antifungal Agents
  • DNA, Fungal
  • Fungal Proteins
  • Peptide Elongation Factors