Correlation of prostate specific antigen immunoactivity (IR-PSA) to other prognostic factors in female breast cancer

Anticancer Res. Jan-Feb 1998;18(1B):683-8.

Abstract

Recently, using an ultrasensitive time-resolved immuno-fluorometric assay, PSA immunoreactivity (IR-PSA) was found in breast tumor cytosols. We retrospectively studied 219 breast cancer patients, measuring IR-PSA in the tumor cytosols, and classified the breast cancers as either PSA positive or PSA negative based on an IR-PSA cut off level of 1 pg/mg. Multivariated analysis showed that IR-PSA is an independent favourable prognostic indicator for postmenopausal, node positive breast cancer patients. Additionally, IR-PSA correlates with reduced risk of relapse in ER+ve tumors and is negatively correlated with mutated p53, which increases the risk of relapse.

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Female
  • Fluorometry
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prognosis
  • Prostate-Specific Antigen / metabolism*
  • Retrospective Studies
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Tumor Suppressor Protein p53
  • Prostate-Specific Antigen