Novel bioactivities of Curcuma longa constituents

J Nat Prod. 1998 Apr;61(4):542-5. doi: 10.1021/np970459f.

Abstract

Bioassay-directed fractionation of ethyl acetate extract from Curcuma longa Linn. rhizomes yielded three curcuminoids, which displayed topoisomerase I and II enzyme inhibition activity. Curcumin III (3) was the most active curcuminoid, inhibiting topoisomerase at 25 micrograms mL-1. Curcumin I (1) and curcumin II (2) inhibited the topoisomerases at 50 micrograms mL-1. Fractionation of the volatile oil from the rhizomes afforded ar-turmerone (4), which displayed mosquitocidal activity with an LD100 of 50 micrograms mL-1 on Aedes aegyptii larvae. Bioassay-directed fractionation of hexane extract from the turmeric leaves yielded labda-8(17),12-diene-15,16 dial (5) with antifungal activity against Candida albicans at 1 micrograms mL-1 and inhibited the growth of Candida kruseii and Candida parapsilosis at 25 micrograms mL-1. In addition, 5 displayed 100% mosquitocidal activity on A. aegyptii larvae at 10 micrograms mL-1.

MeSH terms

  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Asia, Southeastern
  • Bacteria / drug effects
  • Cells, Cultured
  • Circular Dichroism
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Insecticides / isolation & purification
  • Insecticides / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Topoisomerase II Inhibitors

Substances

  • Antifungal Agents
  • Enzyme Inhibitors
  • Insecticides
  • Plant Extracts
  • Topoisomerase II Inhibitors