Structure of locust adipokinetic hormone, a neurohormone that regulates lipid utilisation during flight

Nature. 1976 Sep 16;263(5574):207-11. doi: 10.1038/263207a0.


Adipokinetic hormone, isolated from locust corpora cardiaca, has been identified as a blocked peptide: PCA-Leu-Asn-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2. The detailed structure is based on mass spectrometric data, substantiated in part by dansyl-Edman and carboxypeptidase data on thermolytic fragments. This is the first peptide hormone from an insect neuroendocrine organ to be fully characterised.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / analysis
  • Animals
  • Flight, Animal
  • Grasshoppers / analysis
  • Insect Hormones / analysis*
  • Insect Hormones / physiology
  • Invertebrate Hormones / analysis*
  • Lipid Metabolism
  • Male
  • Mass Spectrometry
  • Structure-Activity Relationship
  • Tryptophan / analysis


  • Amino Acids
  • Insect Hormones
  • Invertebrate Hormones
  • Tryptophan