Neuropathology of preclinical and clinical late-onset Alzheimer's disease

Ann Neurol. 1998 May;43(5):673-6. doi: 10.1002/ana.410430519.


We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal-lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Aged
  • Alzheimer Disease / pathology*
  • Amyloid / analysis
  • Endosomes / pathology
  • Family Health*
  • Female
  • Frontal Lobe / pathology
  • GTP Phosphohydrolases / analysis
  • GTP-Binding Proteins / analysis
  • Humans
  • Lysosomes / pathology
  • Middle Aged
  • Plaque, Amyloid / pathology
  • Pyramidal Cells / chemistry
  • Pyramidal Cells / enzymology
  • Pyramidal Cells / pathology
  • rab5 GTP-Binding Proteins


  • Amyloid
  • GTP Phosphohydrolases
  • GTP-Binding Proteins
  • rab5 GTP-Binding Proteins