Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family

Mamm Genome. 1998 Jun;9(6):463-8. doi: 10.1007/s003359900797.


Here we report the cloning and primary characterization of TIC, a new member of the bHLH/PAS domain family of transcription factors. Northern blot analysis indicates that the 3.3-kb Tic mRNA is widely expressed. A polyclonal antibody against TIC identifies multiple protein species in most cell lines and tissues tested, suggesting that alternative splicing may result in the production of protein isoforms. Interspecies backcross and FISH mapping have been used to localize the Tic gene to mouse Chromosome (Chr) 7 F2-F3, given the locus name Arntl. FISH mapping was also used to localize the human gene to Chr 11p15.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ARNTL Transcription Factors
  • Alternative Splicing
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Basic Helix-Loop-Helix Transcription Factors
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Cloning, Molecular
  • DNA, Complementary / chemistry
  • Helix-Loop-Helix Motifs / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Mice
  • Molecular Sequence Data
  • Trans-Activators / genetics
  • Transcription Factors / genetics*


  • ARNTL Transcription Factors
  • ARNTL protein, human
  • Arntl protein, mouse
  • Basic Helix-Loop-Helix Transcription Factors
  • DNA, Complementary
  • Trans-Activators
  • Transcription Factors
  • endothelial PAS domain-containing protein 1

Associated data

  • GENBANK/AF015953