Predisposing Gene for Early-Onset Prostate Cancer, Localized on Chromosome 1q42.2-43

Am J Hum Genet. 1998 Jun;62(6):1416-24. doi: 10.1086/301879.

Abstract

There is genetic predisposition associated with >=10% of all cancer of the prostate (CaP). By means of a genomewide search on a selection of 47 French and German families, parametric and nonparametric linkage (NPL) analysis allowed identification of a locus, on chromosome 1q42.2-43, carrying a putative predisposing gene for CaP (PCaP). The primary localization was confirmed with several markers, by use of three different genetic models. We obtained a maximum two-point LOD score of 2.7 with marker D1S2785. Multipoint parametric and NPL analysis yielded maximum HLOD and NPL scores of 2.2 and 3.1, respectively, with an associated P value of . 001. Homogeneity analysis with multipoint LOD scores gave an estimate of the proportion of families with linkage to this locus of 50%, with a likelihood ratio of 157/1 in favor of heterogeneity. Furthermore, the 9/47 families with early-onset CaP at age <60 years gave multipoint LOD and NPL scores of 3.31 and 3.32, respectively, with P = .001.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Genetic Heterogeneity
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Lod Score
  • Male
  • Microsatellite Repeats
  • Prostatic Neoplasms / genetics*