[Acute thrombosis of the portal system. Treatment with alteplase and heparin or with heparin alone in 10 patients]

Gastroenterol Clin Biol. 1997;21(12):919-23.
[Article in French]


Objectives: We report the efficacy of alteplase (a recombinant tissue plasminogen activator) with heparin or heparin alone in the treatment of acute thrombosis of the portal venous system.

Methods: Ten consecutive patients with acute portal venous system thrombosis were studied. Five patients were treated with alteplase and heparin, and the remaining 5 patients, who were asymptomatic or had a contraindication to alteplase, were treated with heparin alone.

Results: In 3 of the 5 patients treated with alteplase, ultrasonography showed total resolution of the thrombus; the remaining 2 had partial resolution of the thrombus. In 4 of the 5 patients treated with heparin alone, ultrasonography showed total resolution of the thrombus, and no change in one. No bleeding occurred.

Conclusion: Treatment with heparin can result in complete recanalisation of acute portal venous system thrombosis. These data suggest that combined therapy with systemic alteplase does not increase the efficacy of heparin.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Anticoagulants / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Fibrinolytic Agents / therapeutic use*
  • Heparin / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Portal System*
  • Retrospective Studies
  • Thrombosis / drug therapy*
  • Tissue Plasminogen Activator / therapeutic use*


  • Anticoagulants
  • Fibrinolytic Agents
  • Heparin
  • Tissue Plasminogen Activator