Partial thrombosis of canine carotid bifurcation aneurysms with cellulose acetate polymer

Neurosurgery. 1998 May;42(5):1135-42; discussion 1142-4. doi: 10.1097/00006123-199805000-00108.


Objective: To investigate the usefulness of a cellulose acetate polymer (CAP) solution for partial thrombosis of aneurysms.

Methods: We created 14 canine cervical carotid bifurcation aneurysms, 11 of which were subsequently thrombosed partially with CAP solution. We then conducted angiographic and histological investigations.

Results: Nine aneurysms were thrombosed 50 to 70% by volume, although a significant crescent crevice between the aneurysmal sac and the CAP mass was left in four of the aneurysms. In the remaining two aneurysms in which a crescent crevice had been seen in the initial stage of CAP injection, 80% and more than 95% thrombosis were needed to occlude the crevice, respectively. Follow-up angiograms of the seven aneurysms with no crescent crevice revealed no shifts of position of the CAP mass toward the bottom of the aneurysm sac, but slight ballooning of the remnants was observed in two of them. The angiograms of the other four aneurysms with significant crescent crevices demonstrated rupture with a massive hematoma in one and shifts of the CAP mass with marked enlargement of remnants in three. Histologically, the seven aneurysms with no enlarged remnants had newly developed membranes consisting of endothelium, infiltrated spindle-shaped cells, collagen, and elastic fibers. In contrast, in the three markedly enlarged aneurysms, there were only recent clots between the CAP mass and the aneurysm lumen and no development of endothelium.

Conclusion: Partial thrombosis with CAP solution is useful to keep aneurysms in a stable configuration, unless a crescent crevice has been left.

Publication types

  • Comparative Study

MeSH terms

  • Aneurysm / therapy*
  • Animals
  • Carotid Artery, Common* / diagnostic imaging
  • Carotid Artery, Common* / pathology
  • Cellulose / analogs & derivatives*
  • Cellulose / therapeutic use
  • Dogs
  • Embolization, Therapeutic / methods*
  • Endothelium, Vascular / pathology
  • Evaluation Studies as Topic
  • Polymers
  • Prostheses and Implants
  • Radiography


  • Polymers
  • acetylcellulose
  • Cellulose