Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor

Cancer Invest. 1998;16(4):225-30. doi: 10.3109/07357909809039771.


Macromolecular contrast medium-enhanced magnetic resonance imaging (MRI) and tumor-volume measurements were applied to monitor the effects of anti-vascular endothelial growth factor (anti-VEGF) antibody on microvascular characteristics and tumor growth of MDA-MB-435 human breast cancer cells implanted in nude rats. Administration of anti-VEGF antibody (three 1 mg doses at 3-day intervals) induced significant reductions in tumor growth rates (p < 0.05) and in MRI-assayed microvascular permeabilities (p < 0.05). Results of the study were consistent with previous observations that new microvessels formed in response to angiogenesis are hyperpermeable, and with the hypothesis that hyperpermeability is a mechanistic element in angiogenesis. Variations in tumor-vessel hyperpermeability can be measured by contrast-enhanced MRI, which may prove useful for assessing antiangiogenesis therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / blood supply*
  • Adenocarcinoma / physiopathology
  • Animals
  • Antibodies / pharmacology*
  • Blood Volume / drug effects
  • Breast Neoplasms / blood supply*
  • Breast Neoplasms / physiopathology
  • Capillary Permeability / drug effects*
  • Cell Division / drug effects
  • Endothelial Growth Factors / immunology*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Lymphokines / immunology*
  • Magnetic Resonance Imaging / methods
  • Mice
  • Neoplasm Transplantation
  • Rats
  • Rats, Nude
  • Transplantation, Heterologous
  • Tumor Cells, Cultured
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors


  • Antibodies
  • Endothelial Growth Factors
  • Lymphokines
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors