Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes

J Clin Endocrinol Metab. 1998 May;83(5):1818-20. doi: 10.1210/jcem.83.5.4932.


There is increasing evidence that insulin resistance may be causally related to atherosclerosis. The measurement of common carotid arterial intimal and medial complex thickness (IMT) by B-mode ultrasound technique has been recognized as a powerful and non-invasive method to evaluate early atherosclerotic lesions. We investigated the effect of treatment with troglitazone, an insulin sensitizer, on IMT in a total of 135 Japanese subjects with type 2 diabetes. Troglitazone (400 mg daily) was administered for 6 months in 57 patients. Compared to control group (n = 78), the group given troglitazone showed a significant decrease in IMT as early as 3 months after the administration (IMT change: -0.080[SE 0.016] mm vs. control 0.027[SE 0.007] mm, P < 0.001). The decrease in IMT was also found after 6 months, although further decrease was not observed. Both HbA1c and postprandial serum triglycerides were decreased after troglitazone, but there was no statistically significant relation between a decrease in IMT and those in HbA1c or postprandial triglycerides. These findings indicate that troglitazone has a potent inhibitory effect on progression of early atherosclerotic lesions probably through the decreased insulin resistance in type 2 diabetes.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Carotid Arteries / pathology*
  • Chromans / therapeutic use*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / pathology*
  • Female
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Male
  • Middle Aged
  • Thiazoles / therapeutic use*
  • Thiazolidinediones*
  • Triglycerides / blood
  • Troglitazone


  • Chromans
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Thiazoles
  • Thiazolidinediones
  • Triglycerides
  • Troglitazone