Transfusion-associated graft-versus-host disease in immunocompetent patient: early diagnosis and therapy

Am J Hematol. 1998 May;58(1):84-6. doi: 10.1002/(sici)1096-8652(199805)58:1<84::aid-ajh17>3.0.co;2-5.

Abstract

We report a case of transfusion-associated graft-versus-host disease in a previously healthy, 68-year-old Japanese man following an emergency surgery for an acute aortic dissection. We confirmed the chimerism of lymphocytes and the effect of drug therapy using DNA polymorphism analysis. This method is a sensitive, convenient, and rapid method that it is also useful for the evaluation of therapy. And the combination therapy with methylprednisolone, cyclosporine, and 15-deoxyspergualin may be effective in treating transfusion-associated GVHD.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aortic Aneurysm / surgery
  • Aortic Dissection / surgery
  • Cyclosporine / therapeutic use
  • DNA / genetics
  • Glucocorticoids / therapeutic use
  • Graft vs Host Disease / diagnosis
  • Graft vs Host Disease / drug therapy
  • Graft vs Host Disease / etiology*
  • Guanidines / therapeutic use
  • Humans
  • Immunocompetence*
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Methylprednisolone / therapeutic use
  • Microsatellite Repeats / genetics
  • Polymorphism, Genetic / genetics
  • Time Factors
  • Transfusion Reaction*

Substances

  • Glucocorticoids
  • Guanidines
  • Immunosuppressive Agents
  • Cyclosporine
  • DNA
  • gusperimus
  • Methylprednisolone