Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein

Cell. 1998 May 1;93(3):455-66. doi: 10.1016/s0092-8674(00)81173-3.


Seven transmembrane domain receptors can be localized to different parts of the plasma membrane or to different intracellular compartments in a receptor-specific and cell type-specific fashion. We show here that the C. elegans genes odr-4 and odr-8 are required for localization of a subset of seven transmembrane domain odorant receptors to the cilia of olfactory neurons. Other cilia-signaling proteins, including ion channels, a G alpha protein, and even other receptor types, are localized via an odr-4/odr-8-independent pathway. odr-4 encodes a novel membrane protein that is expressed exclusively on intracellular membranes of chemosensory neurons, where it acts cell-autonomously to facilitate odorant receptor folding or localization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans / chemistry*
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans Proteins*
  • Chemotaxis / genetics
  • Chromosome Mapping
  • Cilia / chemistry
  • Cloning, Molecular
  • Genes, Helminth / genetics
  • Membrane Proteins / analysis
  • Molecular Sequence Data
  • Mutation / genetics
  • Odorants
  • Olfactory Receptor Neurons / chemistry*
  • Promoter Regions, Genetic / genetics
  • Receptors, Odorant / analysis*
  • Receptors, Odorant / genetics
  • Receptors, Odorant / physiology*
  • Recombinant Fusion Proteins


  • Caenorhabditis elegans Proteins
  • Membrane Proteins
  • ODR-10 protein, C elegans
  • ODR-4 protein, C elegans
  • Receptors, Odorant
  • Recombinant Fusion Proteins

Associated data

  • GENBANK/AF055911