Expression of c-fos, fos B, and egr-1 in the medial preoptic area and bed nucleus of the stria terminalis during maternal behavior in rats

Brain Res. 1998 May 11;792(2):348-52. doi: 10.1016/s0006-8993(98)00257-1.


The spatial and temporal pattern of expression of the protein products of immediate early genes (IEGs) c-fos, fos B, and egr-1 were mapped in medial preoptic area (MPOA) and ventral bed nucleus of stria terminalis (VBST) during maternal behavior in rats. Immunocytochemical analysis indicated significant increases in the number of cells expressing c-Fos after 2 h of pup exposure, while Fos B levels showed a delayed response, reaching maximal levels after 6 h.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal / physiology
  • DNA-Binding Proteins / analysis
  • DNA-Binding Proteins / biosynthesis*
  • Early Growth Response Protein 1
  • Female
  • Genes, Immediate-Early / physiology
  • Immediate-Early Proteins*
  • Maternal Behavior / physiology*
  • Preoptic Area / chemistry
  • Preoptic Area / metabolism*
  • Proto-Oncogene Proteins c-fos / analysis
  • Proto-Oncogene Proteins c-fos / biosynthesis*
  • Rats
  • Rats, Inbred Strains
  • Transcription Factors / analysis
  • Transcription Factors / biosynthesis*
  • Zinc Fingers / physiology


  • DNA-Binding Proteins
  • Early Growth Response Protein 1
  • Egr1 protein, rat
  • Immediate-Early Proteins
  • Proto-Oncogene Proteins c-fos
  • Transcription Factors