The therapeutic potential of nitric oxide in lung transplantation

Chest. 1998 May;113(5):1360-71. doi: 10.1378/chest.113.5.1360.


Endogenously produced oxides of nitrogen appear to play important roles in tissue and organ homeostasis. Endogenous production of nitric oxide, which can be altered in response to various stimuli, can modulate vascular tone, oxyradical cascades, cell adhesion, and other aspects of inflammation. Because exogenously administered (inhaled) nitric oxide can mediate pulmonary vasodilatation and improve pulmonary function in some patients with lung injury, treatment of lung allograft recipients with inhaled nitric oxide may ameliorate ischemia-reperfusion injury, thereby improving perioperative pulmonary function and diminishing ventilatory support requirements. This review examines the biology of nitric oxide and present data that support its potential therapeutic effects for lung transplant recipients.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Animals
  • Humans
  • Lung / blood supply
  • Lung / metabolism
  • Lung Transplantation*
  • Nitric Oxide / administration & dosage
  • Nitric Oxide / adverse effects
  • Nitric Oxide / physiology*
  • Nitric Oxide / therapeutic use*
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Nitric Oxide Synthase / physiology
  • Reperfusion Injury / prevention & control*


  • Nitric Oxide
  • Nitric Oxide Synthase