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. 1976 Oct 8;194(4261):193-5.
doi: 10.1126/science.959847.

Structural Basis for ON-and OFF-center Responses in Retinal Ganglion Cells

Structural Basis for ON-and OFF-center Responses in Retinal Ganglion Cells

E V Famiglietti Jr et al. Science. .

Abstract

The inner plexiform layer of the mammalian retina has a bisublaminar organization determined by restricted branching of the terminals of cone bipolar cells and dendrites of class I (large) and class II (small) ganglion cells. Comparison of dendritic field diameters and receptive fiedl center sizes of large ganglion cells suggests that neural circuitry in sublamina a conveys "OFF"-center properties and connections in sublamina b "ON"-center properties to retinal ganglion cells.

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