Structural basis for ON-and OFF-center responses in retinal ganglion cells

Science. 1976 Oct 8;194(4261):193-5. doi: 10.1126/science.959847.


The inner plexiform layer of the mammalian retina has a bisublaminar organization determined by restricted branching of the terminals of cone bipolar cells and dendrites of class I (large) and class II (small) ganglion cells. Comparison of dendritic field diameters and receptive fiedl center sizes of large ganglion cells suggests that neural circuitry in sublamina a conveys "OFF"-center properties and connections in sublamina b "ON"-center properties to retinal ganglion cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cats
  • Dendrites / ultrastructure
  • Ganglia / cytology*
  • Ganglia / physiology
  • Neural Pathways
  • Photoreceptor Cells / cytology
  • Retina / cytology*
  • Retina / physiology
  • Vision, Ocular
  • Visual Fields