Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers

Genes Chromosomes Cancer. 1998 Jun;22(2):152-6. doi: 10.1002/(sici)1098-2264(199806)22:2<152::aid-gcc10>;2-s.


The PTEN/MMAC1/TEP1 gene has been isolated as a tumor suppressor gene that is altered in several types of human tumors including brain, breast, and prostate cancers. In the present study, we report PTEN/MMAC1/TEP1 alterations in human lung cancers. Intragenic homozygous deletions were detected in 6 (40%) of 15 small cell lung carcinoma (SCLC) cell lines and in 2 (8%) of 25 non-small cell lung carcinoma (NSCLC) cell lines. A nonsense mutation and a missense mutation were detected in 2 (8%) NSCLC cell lines. An intragenic homozygous deletion, a 1-bp frameshift mutation, and a nonsense somatic mutation were also detected in three (6%) of 47 surgical specimens. All the lung tumors with PTEN/MMAC1/TEP1 mutations were homozygous for the mutant alleles. These findings suggest that PTEN/MMAC1/TEP1 plays a role as a tumor suppressor gene in the genesis and/or progression of human lung cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Small Cell / genetics*
  • Chromosome Deletion
  • Gene Expression Regulation*
  • Genes, Tumor Suppressor / physiology
  • Genetic Markers
  • Humans
  • Lung Neoplasms / enzymology
  • Lung Neoplasms / genetics*
  • PTEN Phosphohydrolase
  • Phosphoric Monoester Hydrolases*
  • Polymerase Chain Reaction
  • Polymorphism, Single-Stranded Conformational
  • Protein Tyrosine Phosphatases / biosynthesis
  • Protein Tyrosine Phosphatases / genetics*
  • Tumor Suppressor Proteins*


  • Genetic Markers
  • Tumor Suppressor Proteins
  • Phosphoric Monoester Hydrolases
  • Protein Tyrosine Phosphatases
  • PTEN Phosphohydrolase
  • PTEN protein, human