Abstract
Lonchocarpol A, a flavanone, demonstrates in vitro inhibitory activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. This activity is antagonized by mouse plasma, which may account for its lack of in vivo activity. This compound demonstrates no differentiation with respect to the inhibition of RNA, DNA, cell wall, and protein synthesis.
MeSH terms
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Animals
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Bacillus megaterium / drug effects
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Drug Screening Assays, Antitumor
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Enterococcus faecium / drug effects
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Isoflavones / isolation & purification
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Isoflavones / pharmacology*
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Leukemia L1210 / pathology
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Mice
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Microbial Sensitivity Tests
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Moths / chemistry
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Mycobacterium / drug effects
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Staphylococcus aureus / drug effects
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Tumor Cells, Cultured
Substances
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Anti-Bacterial Agents
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Isoflavones
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senegalensin