Phosphatidylinositol signalling reactions

Semin Cell Dev Biol. 1998 Apr;9(2):153-60. doi: 10.1006/scdb.1997.0220.

Abstract

Phosphatidylinositols are important in intracellular signaling. In response to extracellular signals, these molecules undergo rapid turnover and generate second messengers including diacylglycerol, inositol 1,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate (PtdIns 3,4P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3). The importance of phosphoinositide metabolism is underscored by its link to a human genetic disorder oculocerebrorenal syndrome of Lowe in that the gene product (OCRL) deficient in this syndrome is an inositol polyphosphate 5-phosphatase. A new pathway for formation of PtdIns 3,4-P2 and PtdIns 3,4,5-P3 has been found recently. PtdIns 4,5-P2-synthesizing enzymes phosphatidylinositol 4-phosphate 5-kinases (PIP5K) also have kinase activity towards PtdIns 3-P and PtdIns 3,4-P2 forming PtdIns 3,4-P2 and PtdIns 3,4,5-P3 respectively. Surprisingly, they can synthesize PtdIns 3,4,5-P3 directly from PtdIns 3-P in a concerted reaction. PIP5K isozymes may play pivotal roles in intracellular signaling.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Inositol Polyphosphate 5-Phosphatases
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Oculocerebrorenal Syndrome / enzymology
  • Oculocerebrorenal Syndrome / genetics
  • Phosphatidylinositols / physiology*
  • Phosphoric Monoester Hydrolases / genetics
  • Phosphoric Monoester Hydrolases / metabolism
  • Signal Transduction / physiology*

Substances

  • Isoenzymes
  • Phosphatidylinositols
  • Phosphoric Monoester Hydrolases
  • Inositol Polyphosphate 5-Phosphatases