Adaptation in cyclic AMP signalling processes: a central role for cyclic AMP phosphodiesterases

Semin Cell Dev Biol. 1998 Apr;9(2):161-7. doi: 10.1006/scdb.1997.0221.


Cyclic AMP has provided the paradigm for the second messenger concept. Recent evidence has identified a complex array of isoforms of the enzymes involved in generation, destroying and transmitting the effects of this second messenger. These proteins provide a sophisticated system for organising cAMP signal transduction in specific intracellular compartments; for allowing integration with other signalling systems and for controlling the kinetics and hence reaction characteristics of cAMP signal transduction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / physiology*
  • Adaptation, Physiological*
  • Animals
  • Cyclic AMP / physiology*
  • Humans
  • Signal Transduction / physiology*


  • Cyclic AMP
  • 3',5'-Cyclic-AMP Phosphodiesterases