Cloning and characterization of a novel class I cytokine receptor

Biochem Biophys Res Commun. 1998 May 8;246(1):82-90. doi: 10.1006/bbrc.1998.8576.


The human gp130 cDNA sequence was used as a query to search an expressed sequence tag database (dbEST) to identify cDNA sequences with similarity to the cytokine class I receptor family. A novel class I cytokine receptor was identified in a human infant brain cDNA library and was named WSX-1. Full-length cDNA sequences for human and murine WSX-1 were isolated and characterized. The WSX-1 cDNA encodes a 636 amino acid transmembrane protein with an extracellular domain of 482 amino acids and a cytoplasmic domain of 96 amino acids. The structure of the WSX-1 protein most closely resembles that of gp130. Northern blot analysis indicates high levels of expression in thymus, spleen, lymph node, and peripheral blood leukocytes, suggesting a role for WSX-1 in modulation of the immune response.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / metabolism
  • Chromosome Mapping
  • Cloning, Molecular
  • Conserved Sequence
  • DNA Primers / genetics
  • DNA, Complementary / genetics
  • Humans
  • Hybrid Cells
  • Infant
  • Ligands
  • Mice
  • Molecular Sequence Data
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Cytokine / classification*
  • Receptors, Cytokine / genetics*
  • Receptors, Cytokine / metabolism
  • Receptors, Interleukin
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Tissue Distribution


  • DNA Primers
  • DNA, Complementary
  • IL27RA protein, human
  • Il27ra protein, mouse
  • Ligands
  • RNA, Messenger
  • Receptors, Cytokine
  • Receptors, Interleukin

Associated data

  • GENBANK/AF053004
  • GENBANK/AF053005