A dynein light chain of sea urchin sperm flagella is a homolog of mouse Tctex 1, which is encoded by a gene of the t complex sterility locus

Gene. 1998 May 12;211(2):383-6. doi: 10.1016/s0378-1119(98)00128-0.

Abstract

The outer-arm dynein of sea urchin sperm flagella contains six light chains with molecular masses of 23.2, 20.8, 12.3, 11.5, 10.4 and 9. 3kDa. We have cloned a cDNA for the 12.3kDa polypeptide (light chain 3) and found that this protein is highly homologous to mouse Tctex1, a protein encoded by a member of the multigene family in the t complex region that is involved in male sterility and the development of the germ cells. Tctex1 has recently been shown to be homologous to a light chain of cytoplasmic dynein. Therefore, the cytoplasmic dynein light chain has been implicated in the mechanism for the transmission ratio distortion (meiotic drive) that is characteristic of t haplotypes in mice. Our present finding, however, indicates that axonemal light chain 3 must be considered equally important.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chaperonin Containing TCP-1
  • Chaperonins / genetics*
  • Conserved Sequence
  • DNA, Complementary / chemistry
  • DNA, Complementary / genetics
  • Dyneins / chemistry
  • Dyneins / genetics*
  • Genes / genetics*
  • Infertility, Male / genetics*
  • Intracellular Signaling Peptides and Proteins*
  • Male
  • Mice
  • Microtubule-Associated Proteins*
  • Molecular Sequence Data
  • Nuclear Proteins / genetics*
  • Sea Urchins / chemistry
  • Sea Urchins / cytology
  • Sea Urchins / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sperm Tail / chemistry*
  • Spermatozoa / chemistry
  • Ubiquitin-Protein Ligases
  • t-Complex Genome Region

Substances

  • DNA, Complementary
  • Dynlt1b protein, mouse
  • Intracellular Signaling Peptides and Proteins
  • Microtubule-Associated Proteins
  • Nuclear Proteins
  • PPP1R11 protein, human
  • Ubiquitin-Protein Ligases
  • Chaperonin Containing TCP-1
  • Chaperonins
  • Dyneins

Associated data

  • GENBANK/AB004251
  • GENBANK/AB004830