Application of differential cDNA screening techniques to the identification of unique gene expression in tumours and lymphocytes

Curr Opin Immunol. 1998 Apr;10(2):125-30. doi: 10.1016/s0952-7915(98)80239-2.


Development, differentiation and cell death in all organisms are mediated by tightly regulated programs of differential gene expression. Furthermore, changes in gene expression profiles are responsible for tumour formation and tumour progression, as well as for many other human diseases. Thus, the definition of distinct patterns of gene expression is not only essential for understanding complex biological processes but also leads to the identification of novel targets for therapy of various diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA, Complementary / genetics*
  • Gene Expression / genetics*
  • Genetic Techniques*
  • Humans
  • Lymphocytes / metabolism*
  • Neoplasms / genetics*


  • DNA, Complementary