Receptor editing and commitment in B lymphocytes

Curr Opin Immunol. 1998 Apr;10(2):208-13. doi: 10.1016/s0952-7915(98)80250-1.


B cells that fail to pass a developmental checkpoint, either as immature or mature B cells, can be rescued by creating a new B cell antigen receptor through nested secondary immunoglobulin gene rearrangements, a process termed receptor editing. Tolerance-mediated receptor editing occurs in self-reactive immature bone marrow B cells, while peripheral receptor editing probably occurs in low-affinity B cells competing for antigen and for survival signals within the germinal center response.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • Cell Differentiation / physiology
  • DNA Nucleotidyltransferases / physiology
  • Gene Rearrangement / physiology*
  • Humans
  • Immunoglobulins / genetics*
  • Mice
  • Receptors, Antigen, B-Cell / genetics*
  • Signal Transduction / physiology
  • VDJ Recombinases


  • Immunoglobulins
  • Receptors, Antigen, B-Cell
  • DNA Nucleotidyltransferases
  • VDJ Recombinases