Localized amyloidosis and gastrointestinal lymphoma: a rare association

Histopathology. 1998 Apr;32(4):348-55. doi: 10.1046/j.1365-2559.1998.00409.x.


Aims: Five cases of primary gastrointestinal (GI) lymphoma (three in the stomach, one in the ileum (IPSID) and one in the colon) associated with localized AL amyloidosis were studied to identify morphological or immunohistochemical features which could explain the amyloid deposition.

Methods and results: All the cases were low-grade marginal zone B-cell lymphomas; one case of gastric lymphoma and the IPSID also had a high-grade component. The lymphomas had a monoclonal plasma cell population, with different light and heavy-chain type expression in the five cases. Plasma cell differentiation was closely associated with the amyloid deposits. The latter were an incidental microscopic finding in one case, but produced tumoral masses in the other.

Conclusions: The presence of amyloid in primary GI lymphoma is rare, but can have diagnostic value. In the present study, neither particular features of the lymphomatous proliferation nor specific agents are identified. Therefore, the factors predisposing to amyloid deposition require elucidation.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Aged
  • Amyloidosis / complications*
  • Amyloidosis / immunology
  • Amyloidosis / metabolism
  • Amyloidosis / pathology
  • Biomarkers, Tumor / metabolism
  • Gastrointestinal Diseases / complications*
  • Gastrointestinal Diseases / immunology
  • Gastrointestinal Diseases / metabolism
  • Gastrointestinal Diseases / pathology
  • Gastrointestinal Neoplasms / complications*
  • Gastrointestinal Neoplasms / immunology
  • Gastrointestinal Neoplasms / metabolism
  • Gastrointestinal Neoplasms / pathology
  • Humans
  • Immunoglobulin kappa-Chains / metabolism
  • Immunoglobulin lambda-Chains / metabolism
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphocyte Subsets
  • Lymphoma / complications*
  • Lymphoma / immunology
  • Lymphoma / metabolism
  • Lymphoma / pathology
  • Male
  • Middle Aged
  • RNA, Messenger / analysis


  • Biomarkers, Tumor
  • Immunoglobulin kappa-Chains
  • Immunoglobulin lambda-Chains
  • RNA, Messenger