Solitary plasmacytoma of the lung with light chain extracellular deposits: a case report and review of the literature

Histopathology. 1998 Apr;32(4):356-61. doi: 10.1046/j.1365-2559.1998.00393.x.

Abstract

Aims: We present the clinical and histopathological findings of an unusual pulmonary plasmacytoma associated with light chain deposits.

Methods and results: The tumour was located in the main left stem bronchus 40 mm from the carina. Histologically, it was composed of sheets of well differentiated plasma cells. Large extracellular deposits of amorphous material were observed in the tumour. These deposits were Congo red negative and contained kappa light chains. They were electron dense granular and non-filamentous. No plasmacytosis was identified by bone marrow biopsy and no monoclonal spike was shown by serum and urine electrophoresis.

Conclusions: Our case is unusual in being endobronchial and showing light chain deposition.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Humans
  • Immunoglobulin kappa-Chains / metabolism
  • Immunohistochemistry
  • In Situ Hybridization
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / ultrastructure
  • Male
  • Microscopy, Electron
  • Plasmacytoma / diagnostic imaging
  • Plasmacytoma / metabolism
  • Plasmacytoma / pathology*
  • Plasmacytoma / ultrastructure
  • Tomography, X-Ray Computed

Substances

  • Immunoglobulin kappa-Chains