The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire

Immunol Rev. 1998 Apr;162:117-32. doi: 10.1111/j.1600-065x.1998.tb01435.x.


We present here a unifying hypothesis for the molecular mechanism of somatic hypermutation and somatic gene conversion in IgV genes involving reverse transcription using RNA templates from the V-gene loci to produce cDNA which undergoes homologous recombination with chromosomal V(D)J DNA. Experimental evidence produced over the last 20 years is essentially consistent with this hypothesis. We also review evidence suggesting that somatically generated IgV sequences from B lymphocytes have been fed back to germline DNA over evolutionary time.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibody Diversity / genetics
  • Cell Division / genetics
  • Evolution, Molecular
  • Gene Conversion
  • Gene Rearrangement
  • Germ-Line Mutation
  • Humans
  • Immunoglobulin Variable Region / genetics*
  • Models, Genetic*
  • Mutation*


  • Immunoglobulin Variable Region