Successful treatment with voriconazole of invasive aspergillosis in chronic granulomatous disease

Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1694-6. doi: 10.1164/ajrccm.157.5.9709068.

Abstract

A 5-year-old boy with chronic granulomatous disease (CGD) was treated with amphotericin B for an invasive pulmonary Aspergillus nidulans infection. The infection progressed during 6 wk of treatment despite the addition of interferon-gamma (IFN-gamma), filgrastim, and transfusions with donor granulocytes. Treatment with a novel antifungal triazole, voriconazole, resulted in an excellent clinical response.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / complications
  • Aspergillosis / drug therapy*
  • Aspergillus nidulans*
  • Child, Preschool
  • Granulomatous Disease, Chronic / complications*
  • Humans
  • Lung Diseases, Fungal / complications
  • Lung Diseases, Fungal / drug therapy*
  • Male
  • Pyrimidines / therapeutic use*
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Voriconazole