Successful use of extracorporeal membrane oxygenation (ECMO) during BMT for SCID

Bone Marrow Transplant. 1998 Apr;21(8):839-40. doi: 10.1038/sj.bmt.1701185.


An 8-month-old girl with SCID presented with severe bronchiolitis. She received an HLA-identical sibling BMT without conditioning or GVHD prophylaxis. She deteriorated despite mechanical ventilation but had normal cardiac, hepatic and renal function. ECMO was instituted on day +3 and subsequent improvement was seen concurrently with emergence of CD4+ cells on day +11. She was taken off ECMO on day +18 and suffered a left-sided stroke evidenced by a dense left hemiplegia. She was extubated on day +25 and weaned from supplemental oxygen on day +36 and at day +100 has recovered strength in her extremities. This is the first successful use of ECMO as a bridge to engraftment in a BMT patient.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow Transplantation*
  • Extracorporeal Membrane Oxygenation*
  • Female
  • Humans
  • Infant, Newborn
  • Severe Combined Immunodeficiency / therapy*