Chronic stress modulates the virus-specific immune response to latent herpes simplex virus type 1

Ann Behav Med. Spring 1997;19(2):78-82. doi: 10.1007/BF02883323.

Abstract

We compared 71 family caregivers of dementia sufferers and 58 control subjects on three different immune measures relevant to latent herpes simplex virus Type 1 (HSV-1) infection: neutralizing antibody titers, antibody titers to a total viral antigen, and a proliferative memory T-cell response. Caregivers had significantly higher antibody titers to the total viral antigen and a poorer HSV-1 specific T-cell response than controls, but no significant difference in neutralizing antibody titers between groups was observed. These data provide additional evidence that psychological stress can modulate a virus-specific immune response associated with caregiving.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / psychology
  • Antibodies, Viral / immunology*
  • Arousal / physiology*
  • Caregivers / psychology*
  • Dementia / psychology
  • Female
  • Herpes Simplex / immunology*
  • Herpesvirus 1, Human / immunology*
  • Humans
  • Immune Tolerance / immunology
  • Lymphocyte Activation / immunology
  • Male
  • Middle Aged
  • Stress, Psychological / complications*
  • Stress, Psychological / immunology
  • T-Lymphocytes / immunology
  • Virus Latency / immunology

Substances

  • Antibodies, Viral