Cadherin-defined segments and parasagittal cell ribbons in the developing chicken cerebellum

Mol Cell Neurosci. 1998 Apr;10(5-6):211-28. doi: 10.1006/mcne.1998.0665.


In the developing chicken cerebellar cortex, three cadherins (Cad6B, Cad7, and R-cadherin) are expressed in distinct parasagittal segments that are separated from each other by ribbons of migrating interneurons and granule cells which express R-cadherin and Cad7, respectively. The segment/ribbon pattern is respected by the expression of other types of molecules, such as engrailed-2 and SC1/BEN/DM-GRASP. The cadherin-defined segments contain young Purkinje cells which are connected to underlying nuclear zones expressing the same cadherin, thereby forming parasagittal cortico-nuclear zones of topographically organized connections. In addition, R-cadherin-positive mossy fiber terminals display a periodic pattern in the internal granular layer. In this layer, Cad7 and R-cadherin are associated with synaptic complexes. These results suggest that cadherins play a pivotal role in the formation of functional cerebellar architecture by providing a three-dimensional scaffold of adhesive information.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation
  • Avian Proteins
  • Brain Mapping
  • Cadherins / biosynthesis*
  • Cerebellar Cortex / embryology*
  • Cerebellar Cortex / metabolism
  • Cerebellar Nuclei / embryology
  • Cerebellar Nuclei / metabolism
  • Chick Embryo
  • Synapses / metabolism


  • Antigens, Differentiation
  • Avian Proteins
  • Cad7 protein, Gallus gallus
  • Cadherins
  • R-cadherin
  • cad6B protein, Gallus gallus