Acquired perforating dermatosis and diabetic nephropathy--a case report and review of the literature

Clin Exp Dermatol. 1997 Nov;22(6):291-4.


A case of acquired perforating dermatosis associated with diabetic nephropathy is described. The case is unusual in that the dermatosis first developed approximately 1 year after renal transplantation rather than at a time when renal function was more severely impaired or during haemodialysis. There was a partial response to treatment with isotretinoin but the use of this drug was limited by the development of hyperlipidaemia. The relevant literature is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Diabetes Mellitus, Type 1 / complications
  • Diabetic Nephropathies / complications*
  • Humans
  • Hyperlipidemias / chemically induced
  • Isotretinoin / therapeutic use
  • Keratolytic Agents / adverse effects
  • Keratolytic Agents / therapeutic use
  • Kidney Failure, Chronic / complications*
  • Male
  • Skin Diseases / complications*
  • Skin Diseases / drug therapy
  • Skin Diseases / pathology


  • Keratolytic Agents
  • Isotretinoin