Effect of Helicobacter pylori infection on gastric juice pH

Scand J Gastroenterol. 1998 Apr;33(4):357-63. doi: 10.1080/00365529850170973.


Background: How Helicobacter pylori infection affects gastric acid secretion is still unclear.

Methods: Gastric juice pH, ammonia concentration in gastric juice, serum gastrin level, and grade of gastritis in accordance with the Sydney System were determined for patients with gastric ulcer (GU) and duodenal ulcer (DU) before and after treatment with lansoprazole and amoxicillin, and results were compared with those of H. pylori-negative controls.

Results: Scores for H. pylori density, atrophy, metaplasia, and activity of gastritis in the corpus were higher in patients with GU, especially those with proximally located GU, than in those with DU. Gastric juice pH was significantly higher in GU patients than in DU patients and controls. After H. pylori eradication, gastric juice pH and serum gastrin levels in both GU and DU patients were significantly decreased to control levels. In patients without eradication, no significant changes in these factors were observed.

Conclusions: These findings suggest that H. pylori infection and gastritis in the corpus suppress acid secretion and increase gastric juice pH, resulting in hypergastrinemia, and that eradication of H. pylori normalizes acid secretion and serum gastrin levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Ammonia / analysis
  • Amoxicillin / therapeutic use
  • Anti-Ulcer Agents / therapeutic use
  • Case-Control Studies
  • Drug Therapy, Combination
  • Duodenal Ulcer / drug therapy
  • Duodenal Ulcer / metabolism
  • Duodenal Ulcer / microbiology*
  • Female
  • Gastric Acid / metabolism
  • Gastric Juice / chemistry*
  • Gastric Mucosa / pathology
  • Gastrins / blood
  • Gastritis / metabolism
  • Gastritis / microbiology
  • Gastritis / pathology
  • Helicobacter Infections / drug therapy
  • Helicobacter Infections / metabolism*
  • Helicobacter Infections / pathology
  • Helicobacter pylori*
  • Humans
  • Hydrogen-Ion Concentration
  • Lansoprazole
  • Male
  • Middle Aged
  • Omeprazole / analogs & derivatives
  • Omeprazole / therapeutic use
  • Penicillins / therapeutic use
  • Proton Pump Inhibitors
  • Stomach Ulcer / drug therapy
  • Stomach Ulcer / metabolism
  • Stomach Ulcer / microbiology*


  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Gastrins
  • Penicillins
  • Proton Pump Inhibitors
  • Lansoprazole
  • Ammonia
  • Amoxicillin
  • Omeprazole