Genetic basis of salt-susceptibility in the Sabra rat model of hypertension

Kidney Int. 1998 Jun;53(6):1493-500. doi: 10.1046/j.1523-1755.1998.00932.x.


The Sabra salt-sensitive SBH/y and salt-resistant SBN/y rats constitute a unique experimental model of hypertension in which salt-susceptibility is genetically determined and expressed only after salt-loading, without the development of spontaneous hypertension. To determine the genetic basis of salt-susceptibility in the Sabra rats, the candidate gene and total genome screen approaches were adopted. The likely candidate genes in this model incorporate salt-related physiological mechanisms such as the nitric oxide system, the arginine vasopressin axis and the epithelial sodium channel. In the random genome search scheme for culprit genes, SBH/y and SBN/y were cross-bred. A highly unusual and composite mode of transmission of salt-susceptibility was found in this cross, emphasizing the complexity of the genetic basis of salt-susceptibility. Linkage analysis of the entire rat genome with a large number of widely distributed microsatellite markers identified three putative gene loci on chromosomes 1 and 17 that contribute importantly to salt-sensitivity and/or resistance, and uncovered sex specificity in the role that salt-susceptibility genes fulfill in the development of hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromosome Mapping
  • Crosses, Genetic
  • Disease Models, Animal
  • Female
  • Hypertension / genetics*
  • Hypertension / physiopathology*
  • Immunity, Innate / genetics
  • Male
  • Rats
  • Rats, Inbred Strains / genetics*
  • Sodium Chloride / pharmacology*


  • Sodium Chloride