Dynamic changes of 12-lead electrocardiograms in a patient with Brugada syndrome

J Cardiovasc Electrophysiol. 1998 May;9(5):508-12. doi: 10.1111/j.1540-8167.1998.tb01843.x.


We present a patient with Brugada syndrome in whom 12-lead ECGs were recorded just before and after an episode of ventricular fibrillation (VF). A progressive elevation of both the RS-T segment and J waves just preceding and following the VF, and a close relationship between the amplitude of the RS-T segment and the preceding R-R intervals during atrial fibrillation, were documented. These findings support the hypothesis that RS-T elevation and a subsequent VF are related to a transient outward current-mediated spike-and-dome morphology of the epicardial action potential.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bundle-Branch Block / physiopathology*
  • Cardiac Pacing, Artificial
  • Death, Sudden, Cardiac* / prevention & control
  • Electrocardiography* / methods
  • Humans
  • Male
  • Syndrome
  • Ventricular Fibrillation / physiopathology*