Amplification systems based on highly polymorphic tetranucleotide microsatellites from the family of von Willebrand factor gene (vWF) and locus D6S366 repeats are developed at the State Research Center Gos-NII Genetika. A complex expert evaluation of two such molecular genetic individualizing systems based on loci HUMvWFII and D6S366 is performed in order to investigate their probable use in forensic medical personality identification.