Abstract
Magnetic resonance spectroscopy (MRS) is a non-invasive tool for in vivo chemical analysis that has been applied to neurobiological or psychopharmacological studies of affective disorders. Studies employing 31P-MRS and 1H-MRS have indicated possible abnormalities in membrane phospholipid metabolism, high-energy phosphate metabolism, and intracellular pH in affective disorders. They have also suggested that lithium increases the phosphomonoester (possibly inositol-1-phosphate) peak in the brain but does not increase that of choline-containing compounds in the brain. Studies employing 7Li-MRS and 19F-MRS have elucidated the pharmacokinetic properties of lithium, fluoxetine, and fluvoxamine in the brain in patients treated with these drugs.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Affect / physiology
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Animals
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Antidepressive Agents, Second-Generation / pharmacokinetics
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Antipsychotic Agents / pharmacology
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Basal Ganglia / drug effects
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Basal Ganglia / metabolism
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Bipolar Disorder / drug therapy
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Bipolar Disorder / physiopathology
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Brain Chemistry* / drug effects
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Depression / drug therapy
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Depression / physiopathology
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Energy Metabolism
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Fluorine Radioisotopes / pharmacokinetics
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Frontal Lobe / drug effects
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Frontal Lobe / metabolism
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Humans
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Hydrogen
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Lithium / pharmacology
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Magnetic Resonance Spectroscopy* / methods
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Membrane Lipids / metabolism
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Mood Disorders / drug therapy
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Mood Disorders / physiopathology*
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Phosphorus Radioisotopes
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Radioisotopes / pharmacokinetics
Substances
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Antidepressive Agents, Second-Generation
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Antipsychotic Agents
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Fluorine Radioisotopes
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Membrane Lipids
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Phosphorus Radioisotopes
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Radioisotopes
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Hydrogen
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Lithium