Quetiapine (Seroquel) in the treatment of psychosis in patients with Parkinson's disease

J Neuropsychiatry Clin Neurosci. 1998 Spring;10(2):216-9. doi: 10.1176/jnp.10.2.216.


Psychoses are a common clinical problem in patients with Parkinson's disease. Treatment with typical neuroleptics or withdrawal of antiparkinsonian drugs may improve mental symptoms but will worsen the parkinsonism. Quetiapine (Seroquel), ICI 204,636, is a novel antipsychotic medication with a low potential for producing extrapyramidal side effects. In this open-label clinical study of 2 patients with Parkinson's disease, treatment with Seroquel successfully controlled psychotic symptoms without worsening of motor disability.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Aged
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Dibenzothiazepines / therapeutic use*
  • Dyskinesia, Drug-Induced / prevention & control
  • Female
  • Humans
  • Male
  • Parkinson Disease / complications*
  • Psychotic Disorders / complications
  • Psychotic Disorders / drug therapy*
  • Quetiapine Fumarate
  • Severity of Illness Index
  • Treatment Outcome


  • Antipsychotic Agents
  • Dibenzothiazepines
  • Quetiapine Fumarate