Neuroleptic sensitivity to clozapine in dementia with Lewy bodies

J Neuropsychiatry Clin Neurosci. Spring 1998;10(2):227-9. doi: 10.1176/jnp.10.2.227.


Dementia with Lewy bodies (DLB) may be one of the most common causes of dementia. It should be of particular interest to psychiatrists because hallucinations are common presenting symptoms and because patients with DLB may be particularly sensitive to neuroleptics with respect to developing extrapyramidal symptoms. The authors describe 2 patients with DLB who were intolerant of clozapine, showing not extrapyramidal side effects, but an increase in confusion and behavioral symptoms.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antipsychotic Agents / adverse effects*
  • Clozapine / adverse effects*
  • Confusion / chemically induced*
  • Dementia / drug therapy*
  • Dementia / pathology
  • Humans
  • Lewy Bodies*
  • Male
  • Psychoses, Substance-Induced*


  • Antipsychotic Agents
  • Clozapine