Demyelinating neuropathy in a patient with multiple sclerosis and genotypical HMSN-1

Neuromuscul Disord. 1998 Apr;8(2):87-9. doi: 10.1016/s0960-8966(98)00016-9.


Patients with multiple sclerosis (MS) may develop a peripheral neuropathy, sometimes attributed to nutritional deficiency. Other patients present with a demyelinating neuropathy which is presumed to be the result of an autoimmune process that affects both the central and peripheral nervous systems. We report a case of concurring MS and demyelinating neuropathy, without a positive family history, in whom genetic testing proved the neuropathy to be hereditary and not autoimmune. Hereditary neuropathy should be a consideration in sporadic cases of peripheral neuropathy and MS.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Charcot-Marie-Tooth Disease / diagnosis
  • Charcot-Marie-Tooth Disease / genetics*
  • DNA / analysis*
  • Demyelinating Diseases / diagnosis
  • Demyelinating Diseases / genetics*
  • Diagnosis, Differential
  • Evoked Potentials / physiology
  • Female
  • Genotype
  • Humans
  • Magnetic Resonance Imaging
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / genetics*


  • DNA