Malignant meningioma of the oculomotor nerve without dural attachment. Case report and review of the literature

J Neurosurg. 1998 Jun;88(6):1104-6. doi: 10.3171/jns.1998.88.6.1104.


Meningiomas, thought to arise from arachnoid cap cells, are usually attached to the dura. Malignancy is present in approximately 1% of these tumors. The authors report the case of a patient with a malignant meningioma arising from the oculomotor nerve with no dural attachment. The patient presented with a 7-month history of left-sided ptosis and diplopia. Magnetic resonance imaging demonstrated an extrinsic mass compressing the root of the oculomotor nerve at its exit from the midbrain. During surgery, a left-sided subtemporal approach revealed the tumor to be arising from the oculomotor nerve. Histological investigation showed a malignant spindle cell lesion with an immunohistochemical profile that was consistent with malignant meningioma. To the authors' knowledge, this is the first documented case of a malignant meningioma arising from the oculomotor nerve.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Arachnoid / pathology
  • Blepharoptosis / diagnosis
  • Cranial Nerve Neoplasms / diagnosis*
  • Cranial Nerve Neoplasms / pathology
  • Diplopia / diagnosis
  • Dura Mater / pathology
  • Female
  • Glial Fibrillary Acidic Protein / analysis
  • Humans
  • Immunohistochemistry
  • Meningioma / diagnosis*
  • Meningioma / pathology
  • Mucin-1 / analysis
  • Oculomotor Nerve / pathology*
  • Paralysis / diagnosis
  • S100 Proteins / analysis
  • Vimentin / analysis


  • Glial Fibrillary Acidic Protein
  • Mucin-1
  • S100 Proteins
  • Vimentin