Total and regional bone mass and biochemical markers of bone remodeling in metastatic prostate cancer

Prostate. 1998 Jun 1;35(4):243-7. doi: 10.1002/(sici)1097-0045(19980601)35:4<243::aid-pros2>;2-h.


Background: The osteolytic activity of metastases of prostate cancer was evaluated in relation to total body bone mineral content (TBBMC) and regional bone mineral content (RBMC).

Methods: Bone mass was determined by dual-energy X-ray absorptiometry (DXA). Tartrate-resistant acid phosphatase (TRAP) was measured as a biochemical marker of bone resorption.

Results: In 32 patients (mean age 72+/-4 years) compared with 32 controls (mean age 73+/-5 years), there were significant differences in TRAP (P < 0.0001), TBBMC (P < 0.0001), and RBMC in the pelvis (P < 0.0001), legs (P=0.0001), and trunk (P<0.05), but not in the arms and head (P=ns). In the overall group of subjects, the correlation between TBBMC and TRAP was r=-0.68, P < 0.0001. The correlations remained significant in the patient and control groups separately.

Conclusions: The loss of bone mass observed in patients with metastatic prostate cancer was caused mainly by the predominance of bone resorption in the osteoblastic metastases.

Publication types

  • Comparative Study

MeSH terms

  • Absorptiometry, Photon
  • Acid Phosphatase / blood
  • Aged
  • Alkaline Phosphatase / blood
  • Analysis of Variance
  • Biomarkers / blood
  • Biomarkers / urine
  • Bone Density*
  • Bone Neoplasms / pathology
  • Bone Neoplasms / physiopathology
  • Bone Neoplasms / secondary*
  • Bone Remodeling*
  • Bone Resorption*
  • Calcium / urine
  • Humans
  • Isoenzymes / blood
  • Male
  • Neoplasm Metastasis
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / physiopathology*
  • Prostatic Neoplasms / urine
  • Reference Values
  • Regression Analysis
  • Tartrate-Resistant Acid Phosphatase


  • Biomarkers
  • Isoenzymes
  • Alkaline Phosphatase
  • Acid Phosphatase
  • Tartrate-Resistant Acid Phosphatase
  • Calcium