Centromeres: proteins, protein complexes, and repeated domains at centromeres of simple eukaryotes

Curr Opin Genet Dev. 1998 Apr;8(2):212-8. doi: 10.1016/s0959-437x(98)80143-3.


Similarities exist among components of simple and complex centromeres that may not have been expected on the basis of wide variation in size and sequence organization of centromeric DNAs among eukaryotes. Support is growing in systems from fungi to Drosophila for a model of centromere assembly and activation that is dependent on a particular underlying chromatin structure but not necessarily on a specific DNA sequence.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Centromere*
  • DNA
  • Drosophila melanogaster / genetics
  • Eukaryotic Cells
  • Genes, Insect
  • Humans
  • Kinetochores
  • Models, Genetic
  • Nuclear Proteins / metabolism*
  • Nucleic Acid Conformation
  • Saccharomyces cerevisiae
  • Schizosaccharomyces


  • Nuclear Proteins
  • DNA