Mechanisms of silencing in Saccharomyces cerevisiae

Curr Opin Genet Dev. 1998 Apr;8(2):233-9. doi: 10.1016/s0959-437x(98)80146-9.


In the yeast Saccharomyces cerevisiae, heterochromatin-like regions are formed at the silent mating type loci and at telomeres. The past year of investigations has led to a clearer understanding of the nature of nucleation and spreading of heterochromatin, as well as uncovering a fascinating link between silencing, the nucleolus and aging.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Nucleolus
  • Chromatin
  • DNA Repair
  • DNA Replication
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Humans
  • Ligands
  • Saccharomyces cerevisiae / genetics*
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae*
  • Telomere
  • Ubiquitins / metabolism


  • Chromatin
  • Fungal Proteins
  • Ligands
  • SIR4 protein, S cerevisiae
  • Silent Information Regulator Proteins, Saccharomyces cerevisiae
  • Ubiquitins