Abstract
Repetitive chromatography of the methanol extract of the roots of Gentiana tibetica afforded two new secoiridoid glycosides and a novel antifungal anthranilic acid derivative, together with beta-sitosterol, daucosterol, oleanolic acid, loganic acid, gentiopicroside, sweroside, 2'-(2,3-dihydroxybenzoyl)sweroside, trifloroside, rindoside and macrophylloside A. The structures of the new products were determined mainly by spectroscopic methods as 8-hydroxy-10-hydrosweroside, isomacrophylloside and ethyl N-docosanoylanthranilate. Ethyl N-docosanoylanthranilate inhibited the growth of the human pathogenic fungi Candida albicans and Aspergillus flavus. The taxonomic significance of the constituent is discussed briefly.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Aspergillus flavus / drug effects
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Candida albicans / drug effects
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Carbohydrate Conformation
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Chromatography, Gel
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Chromatography, Ion Exchange
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Iridoid Glucosides
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Iridoids*
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Magnetic Resonance Spectroscopy
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Medicine, Chinese Traditional
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Plant Roots / chemistry*
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Plants, Medicinal / chemistry*
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Pyrans / chemistry
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Pyrans / isolation & purification*
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Pyrans / pharmacology
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ortho-Aminobenzoates / chemistry
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ortho-Aminobenzoates / isolation & purification*
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ortho-Aminobenzoates / pharmacology
Substances
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10-hydro-8-hydroxysweroside
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Antifungal Agents
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Glucosides
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Iridoid Glucosides
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Iridoids
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Pyrans
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ethyl N-docosanoylanthranilate
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isomacrophylloside
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ortho-Aminobenzoates