Abstract
The serum levels of the beta-chemokine RANTES and, albeit less, MIP-1 beta were found to be increased in 37 HIV-1 infected compared to seronegative individuals. In contrast the serum levels of IL-16 were only sporadically elevated in seropositives as well as in seronegatives. Concomitantly, the RANTES gene expression increased about tenfold in seropositives, whereas the MIP-1 beta and IL-16 mRNA levels were not elevated. No correlation between the increase of the MIP-1 beta and RANTES serum concentrations and the plasma virus load, the number of the peripheral CD4+ T cells or the therapy status of the patients was found. However, the increased proportion of activated CD8+CD38+ T cells in the peripheral blood of all seropositives paralleled the increased RANTES serum levels detected indicating that immune activation in HIV-1-infected individuals may contribute to increased RANTES serum levels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Adult
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Anti-HIV Agents / therapeutic use
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Antigens, CD*
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Antigens, Differentiation / immunology
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CD8-Positive T-Lymphocytes / immunology*
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Chemokine CCL4
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Chemokine CCL5 / blood*
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Chemokine CCL5 / genetics
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HIV Infections / blood
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HIV Infections / drug therapy
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HIV Infections / immunology*
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Humans
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Interleukin-16 / blood
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Interleukin-16 / genetics
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Leukocytes, Mononuclear / immunology
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Lymphocyte Activation*
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Lymphocyte Count
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Macrophage Inflammatory Proteins / blood
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Macrophage Inflammatory Proteins / genetics
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Membrane Glycoproteins
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NAD+ Nucleosidase / immunology
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RNA, Messenger
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T-Lymphocytes / immunology*
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Viral Load
Substances
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Anti-HIV Agents
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Antigens, CD
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Antigens, Differentiation
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Chemokine CCL4
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Chemokine CCL5
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Interleukin-16
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Macrophage Inflammatory Proteins
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Membrane Glycoproteins
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RNA, Messenger
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ADP-ribosyl Cyclase
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CD38 protein, human
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NAD+ Nucleosidase
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ADP-ribosyl Cyclase 1