The number of road vehicle accidents during travel outside Europe and/or under difficult conditions increases about 5% every year. Road accidents account for a third to half of medical evacuations as well as for the most serious injuries. The risk of accidents and their potential gravity may be enhanced by the poor condition of roads and vehicles. Personal factors including fatigue, speed, alcohol, drugs, and poor vision also play a major role. Physicians should warn travelers planning road trips of all these hazards and of any specific local conditions prevailing in certain destinations. Prevention depends on the age of the traveler and on any disabilities that he/she might have. Packing a first aid kit and inspecting safety equipment before the trip and at regular intervals during the trip are indispensable. Knowledge of emergency first aid procedures is highly recommendable. While avoiding excessiveness of any kind, the physician should encourage suitable psychological and material preparation in function of travel plans. This preparation should be aimed at reducing the risk of road accident particularly in developing countries. Counseling can be useful in reducing the risk of road accidents particularly in developing countries.