The effect of ketamine pretreatment on propofol injection pain in 100 women

Anaesthesia. 1998 Mar;53(3):302-5. doi: 10.1046/j.1365-2044.1998.00287.x.

Abstract

A controlled, randomised double-blind study was performed to compare the prior intravenous administration of ketamine 10 mg (1 ml) or 0.9% saline (1 ml) on propofol injection pain. One hundred patients of ASA status 1 or 2 presenting for gynaecological surgery were studied. Following an initial 5-ml bolus of propofol into a dorsal hand vein, 30 s after the treatment, 84% of the saline control patients experienced mild or severe pain compared to 26% of those who were given ketamine pretreatment (p < 0.05).

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anesthetics, Dissociative / therapeutic use*
  • Anesthetics, Intravenous / adverse effects*
  • Double-Blind Method
  • Female
  • Humans
  • Injections, Intravenous / adverse effects
  • Ketamine / therapeutic use*
  • Middle Aged
  • Pain / chemically induced
  • Pain / prevention & control*
  • Propofol / adverse effects*
  • Prospective Studies

Substances

  • Anesthetics, Dissociative
  • Anesthetics, Intravenous
  • Ketamine
  • Propofol